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Arthritis and Rheumatology Clinical Trials

About Arthritis, Rheumatology and Bone Health

The Primary disease focus is rheumatoid arthritis, osteoarthritis and osteoporosis. Researchers also capitalize on scientific opportunities that emerge from primary research focus, including the development of novel therapies for tumor-induced hypercalcaemia and fracture repair. Some research may also provide benefit in other inflammatory conditions such as asthma, dermatitis and autoimmune diseases.

Arthritis, Rheumatology and Bone Health Clinical Trials at Novartis

At Novartis, new medications are being developed to treat the symptoms and the underlying causes of several of the main conditions affecting bones and joints. Currently, Novartis is exploring a number of novel compounds via arthritis and rheumatology clinical trials that may apply to some of the following conditions listed below.

Osteoporosis
One in two women and one in eight men over 50 will have an osteoporosis-related fracture in their lifetime. Different approaches are available to increase the rate of new bone formation and slowing the rate of its removal. Newer medications are being investigated.

Osteoarthritis
This common degenerative joint disease is an expression of 'wear-and-tear'. Thus athletes or overweight people develop osteoarthritis in large joints (knees, shoulders, hips) due to loss or damage of cartilage. When cartilage is lost, the bone next to the joint is also eroded. New medications are being investigated.

Rheumatoid arthritis
In this chronic disease various joints in the body are inflamed, leading to swelling, pain, stiffness, and possibly loss of function. Continuous inflammation gradually erodes the joint cartilage, narrows the joint space and eventually damages bone. The inflammatory process not only affects the joints but can also harm organs in other parts of the body.


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